Nature of Wires was formed in 1986 in Herefordshire, UK. The original line-up was Gary Watts and Andrew Stirling-Brown. In 1993 vocalist Sarah Bouchier, aka Lady B, joined, but the following year the band decided to take a "6-month" break, which would last more than 20 years!

In 2015 NoW reformed and joined forces with US vocalist CountessM. In 2016 they released Cyber Rendezvous on the UK's AnalogueTrash label, which was the first album since 1993’s Modus Operandi. Also in 2016 Tim Powell-Tuck joined on electronic drums. In November 2018 Lady B returned, making her second debut at Manchester’s iconic Ruby Lounge. NoW has appeared with many giants of the electronic scene, including Empathy Test, Aesthetic Perfection, Lord of the Lost and Leaether Strip and more shows are planned for 2019, with sights set on festivals in the UK and mainland Europe.

NoW released "Reborn", a four-track EP which features Lady B on vocals, on Germany's Echozone label on April 26th 2019. The first single from the EP "Try" reached number 9 in the German Alternative Charts. The band is currently finalising the next album, Modus, with Andrew on lead vocals (it was written before Lady B rejoined), which will be released on AnalogueTrash in the summer of 2019, with remixes from Mesh, Leaether Strip, Cyferdyne & more. NoW has also created remixes for dozens of international artists including Massive Ego, Leaether Strip, Sigue Sigue Sputnik Electronic, !distain, Freakangel, Machine Rox & Vogon Poetry.